Learning a Complete Image Indexing Pipeline

To work at scale, a complete image indexing system comprises two components: An inverted file index to restrict the actual search to only a subset that should contain most of the items relevant to the query; An approximate distance computation mechanism to rapidly scan these lists. While supervised deep learning has recently enabled improvements to the latter, the former continues to be based on unsupervised clustering in the literature. In this work, we propose a first system that learns both components within a unifying neural framework of structured binary encoding

Gradient-based Regularization Parameter Selection for Problems with Non-smooth Penalty Functions

<p>In high-dimensional and/or non-parametric regression problems, regularization (or penalization) is used to control model complexity and induce desired structure. Each penalty has a weight parameter that indicates how strongly the structure corresponding to that penalty should be enforced. Typically the parameters are chosen to minimize the error on a separate validation set using a simple grid search or a gradient-free optimization method. It is more efficient to tune parameters if the gradient can be determined, but this is often difficult for problems with non-smooth penalty functions. Here we show that for many penalized regression problems, the validation loss is actually smooth almost-everywhere with respect to the penalty parameters. We can therefore apply a modified gradient descent algorithm to tune parameters. Through simulation studies on example regression problems, we find that increasing the number of penalty parameters and tuning them using our method can decrease the generalization error.</p

Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways-5

measured by flowcytometry as described in the Material and Methods. The shift-down of fluorescence from Red to Green indicates the collapse of mitochondrial membrane potential. CCCP was used as a positive control for the disruption of mitochondrial membrane potential. The percent of cells with the disruption of mitochondrial membrane potential was indicated.<p><b>Copyright information:</b></p><p>Taken from "Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways"</p><p>http://www.jhoonline.org/content/1/1/6</p><p>Journal of Hematology and Oncology 2008;1():6-6.</p><p>Published online 9 Jun 2008</p><p>PMCID:PMC2438442.</p><p></p

Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways-6

or 72 hours. The cell number was recorded at each time point. Diamond (♦), control; Square (■), 0.1 μM; Triangle (), 0.5 μM; Dot (●); 5.0 μM. (B). PHI induces G1 growth arrest. The myeloma cells were cultured with 0.5 μM of PHI for 48 or 96 hours. The cellular DNA content was determined by flow cytometry. Values are means +/- SD from 3 independent experiments. Open bar, G1 phase; Black bar, G2M phase; Grid bar, S phase.<p><b>Copyright information:</b></p><p>Taken from "Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways"</p><p>http://www.jhoonline.org/content/1/1/6</p><p>Journal of Hematology and Oncology 2008;1():6-6.</p><p>Published online 9 Jun 2008</p><p>PMCID:PMC2438442.</p><p></p

Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways-4

Diamond (♦), control; Square (■), 0.1 μM; Triangle (), 5 μM; Cross (x), 10 μM. (B). Percent inhibition of VEGF production as compared with the control culture was calculated from the above experiments. Values are means +/- SD from 3 independent experiments. Open bar, 24 hours; Black bar, 48 hours.<p><b>Copyright information:</b></p><p>Taken from "Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways"</p><p>http://www.jhoonline.org/content/1/1/6</p><p>Journal of Hematology and Oncology 2008;1():6-6.</p><p>Published online 9 Jun 2008</p><p>PMCID:PMC2438442.</p><p></p